I made a small program with AutoIt to make abilities fire instantly, bypassing the "cross hairs" + click and just executing the ability at the cursor position for slots 1 through 3. Also made a script for "buffs" using the second Quickbar, they are bound to F1 through F3. By pressing F1 it will instantly swap to the second bar, press 1, then swap back to the first bar instantly, you won't even see the bars swap it happens so fast. This frees up space on the main Quickbar by placing buffs on the 1st, 2nd, and 3rd slots on the second Quickbar.
How this works:
Slots 1, 2 ,3 on the main bar are "Quickfire" slots, meaning the macro right clicks instantly after you press the button. Lets use Defense Mastery Abilities for these examples. By putting Shield Charge in slot 1 traditionally you would get a targeting cross hair when pressed, then you would click to charge in. With this program now you just press 1 and you charge to the target immediately, no cross hairs+click. The rest of the slots on the main bar (4 -> 0) work normally.
Slots 1, 2, 3, on the Second Quickbar are setup differently. I set these slots up for "buffs," like Battle Awareness. They are bound with F1, F2, F3 (traditionally bound to target pets, and these will need to be cleared in the keybinding options in game) By pressing F1 (in this case we have Battle Awareness set to slot 1) the macro will swap to the second bar, press 1 enabling Battle Awereness, then return to the main Quickbar, it executes fast enough that you don't see the bars swap. The rest of the slots on Quickbar 2 (4 -> 0) work normally.
Quickbar slots 1, 2, and 3, must be bound to 1, 2, 3, in-game for this to work.
F1, F2 and F3 need to be unbound from Pet Targeting in-game for this to work properly.
Edit: Swap Quickbars must be bound to Y in-game.
This is an .exe that loads in the system tray and only works in TQIT, so it wont mess things up if its running and you are using these keys in another app. Simply right click it in the system tray to close it after exiting TQIT.
I hope this is useful for some of you, it makes the combat system much smother for me. If any of you have requests, like adding more slots, let me know and I will recompile and upload it.
Thanks to Jowshie I got this thing perma hosted. The file contains AutoIt (the only version that works with TQ), two scripts, two .exe's 1-4 and 1-10, and instructions on how to make your own.