What race your character is? I usually played as Varani who have +2 to Lockpicking, and didn't put any points in it until level 10-12. Higher skill level prevents lockpicks from to breaking immediately when in wrong position, but if you have a lot of them you can spare some. And try to listen to the scratching sound when picking a lock, it sounds different when lockpick is about to break...And how fast it breaks indicates how far you're from the right angle.
I never got into Dispelling minigame, so at first levels just ignored cursed chests, and then invested some points, so it won't explode after wrong attempt, and used Auto-attempt.
Piece of advice - even if you don't plan to craft you own items (but it's very good with the right materials), invest a couple of points in Blacksmithing and always use repair kits instead of repairing in a shop. Repair kits are very cheap, while blacksmith's prices become insane when you get good gear.
Check this site: http://amalurfoundry.com/
It has a talent calculator, some guides and other useful things.
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Is it really that difficult to put basic info where it can be found by players? I suppose they could go in the quick slots, but I don't really want loads of different potions cluttering it up when I may need the slots for other things.
Another thing missing that TQIT got right years ago.
