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Originally Posted by LowMoose
I'm hoping to start a long game with a buddy that we'll play exclusively together. One of us is probably going to go the alchemy/close combat route for wiping out groups, but that's not too great when it comes to taking down bosses. So what's a good mastery combo for destroying really big and nasty single targets?
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I find that bosses are best if you somehow melee, because some monsters seem scripted to not use certain attacks if they are engaged in melee. For instance, if you melee the boss in "Outpost in the Woods", he won't use his area-effect attack. Similarly, the huge automatons in the final areas of Hades won't set off their lightning surges if engaged in melee.
Just about anything can be taken down going toe-to-toe if you have a high DPS and a good Damage-to-Health conversion. Undead are harder, but if you can get something that will reduce their resistance to Life Leech, this strategy will also work.
That said, I've actually done melee with a Diviner in the old game precisely because she could raise an emanation that gave high vulnerability to life leeching (and other things).
Also, anything that has reliable Skill Disruption is also useful. Come to think of it, they might not have been using certain abilities because of Skill Disruption...
Whatever you do, get Stun Resistance, and lots of it. Even with 112%, you can still be stunned in Epic for a half second or so!