I'll try to post this as complete as I can:
1)Programs like TQ Chest/TQ Vault will probably work, unless the file format has changed considerably (doubtful), but for sure will have issues with the new items, and neither will be able to make your character work again as neither will have the ability to hack the game until they are updated (or the Defiler in TQ Chest's case). The mods will not work (if they are built-in) in the TQ Vault as well.
2)TQ Hades and other programs by Raven, myself, S_L, etc. will not work as the locations for the mods/hacks will need to be updated.
3)The Defiler should still work for loading characters, BUT you do not want to edit anything, because the locations for patching/fixing will need to be updated after I find them, and until I have money again (enough to pre-order/buy the expansion) that could be awhile after it comes out. The Defiler will tell you your version has changed and it won't let you use the hacks/mods to intentionally mess up something. The only use it will have is for backing up or looking at your character, anything else for the most part is version-specific and will not work.
P.S. Removing TQ Vault will not hurt anything, just make sure you don't delete your vault files (with items in them) and make sure you have your characters showing in-game first. You can find a thread on this site or my forums (
DT Forums :: Index look under SoulSeekkor's Defiler/Portable) with links to the original game files you may need to be able to install IT without having to reinstall Titan Quest.