TQ is not an item-grinding game like D2. While it may have quite a lot of affixes, it does not have anything like a closed B-net that makes it interesting to grind Levels and Items.
It will (hopefully) get its replayability value by the editor and player-generated Maps/Stories, not by the "item fever", which destroyed gameplay in closed B-net, although it certainly increased the longetivity of D2.
I would not mind anything that you feared. While i liked teleport, it was mostly abused for quickly getting to your goal withouth killing anything in the end. Items are nice to have, but nothing that should be more important than game play. So i will miss neither %Item nor anything else that encourages something like Pindel runs.
While the Skill timers might need some adjusting for some skills, they are very important imho. Mana is useless for balancing out strong skills against weaker skills. And the ability to spam your best skill over and over without ever having to use different skills made D2 very monotonous and too easy. Especially AOE was too easily available. Personally, i would not mind if timer-dependant skills were used more often instead of simple buffs in TQ
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