The exit button automatics saves (it actually says so, when you exit
).
And as far as autosafe goes, I don't know how it works, but I had 2 crashes while I played, and I'm pretty sure it had saved all of my progress up untill the crash (I had just completet a quest, wich was still completet, but can't say for sure about loot in my inv). You just start at your last Rebirth Fountain