[The Rock-man]

The problem is you need saphos -resist to pull this off, saphos is king of all weapons. Assassin is the best build for really high poison damage saphos & a poison weapon. If you using an other build then how about this land a it with saphos then switch to your poison weapon.

If you worried about survivability then Corsair be best and has good damage as well. The best poison damage be from dreamkiller as ToW and Saphos stack! Any mob with more then 0 poison resist will take more damage due to ToW and Sap[hos works on everything.
Note landing a hit with Saphos for the -resists the switching to you high damage sword or spear is the best thing to do as then for ~3 secs you will do mega damage.

Saphos will always be more effective then ToW as mobs need to have ~200% resistances to most of your damage types for ToW to give an equal reduction in which case -resist will be useless anyway. Also Saphos can take resist below 0 with or without ToW whereas ToW can only reduce current resists by its %age.